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标题:Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability.
时间:2020-02-15 14:48:27
DOI:10.1007/s00018-018-2837-5
PMID:29766217
作者:Pál; Balázs
出版源: 《Cellular & Molecular Life Sciences》
摘要:Glutamate is the most abundant neurotransmitter of the central nervous system, as the majority of neurons use glutamate as neurotransmitter. It is also well known that this neurotransmitter is not...
大小:1898 kb
页数:34 PAGES
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目录:
  • Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability
    • Abstract
    • Introduction
    • Extrasynaptic glutamatergic signaling of the central nervous system
      • Sources of eGlu
        • Neurons: diffusion from synaptic cleft
        • Astrocytes
        • Microglia and oligodendroglia
      • Concentration, diffusion
        • Concentrations of glutamate in different compartments of the extracellular space in the CNS
        • Limitations of diffusion in the extracellular space
      • Glutamate receptors
        • Extrasynaptic NMDA receptors
        • Extrasynaptic AMPA receptors
        • Extrasynaptic mGluRs
      • Uptake and metabolism
      • Ionic currents elicited by extrasynaptic glutamate
      • Methods for investigating extrasynaptic glutamatergic actions
    • Physiology
      • Setting of neuronal excitability via phasic and tonic changes of the neuronal resting membrane potential
      • Neuroendocrine regulation and participation in neuromodulatory actions
      • Contribution to sleep–wakefulness cycles and global brain states
      • Modulation of synaptic strength; homeostatic synaptic plasticity
      • Long-term synaptic plasticity
    • Involvement of eGlu in the pathogenesis of neurological diseases
      • Normal aging
      • Alzheimer’s disease
      • Stroke, ischemia, traumatic brain injury
      • Epilepsy
      • Mood disorders
      • Schizophrenia
      • Addiction
      • Multiple sclerosis
      • Huntington’s disease
      • Amyotrophic lateral sclerosis
      • Glioma
    • Concluding remarks
    • Acknowledgements
    • References

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