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标题:Synthesis of glycoimmunogen Tn-Thr-PS A1 via hydrazone bond and stability optimization of PS A1 monosaccharide mimics under vaccine development conditions
时间:2020-02-15 11:05:57
DOI:10.1080/07328303.2019.1709975
作者:F. Hossain;S. Nishat;S. Ghosh
大小:2554 kb
页数:25 PAGES
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目录:
  • Abstract
    • Introduction
    • Results and discussions
      • PS A1 isolation
      • Synthesis of Tn-Thr-PS A1
      • Factors effecting hydrolysis of pyruvate acetal on the D-galactopyranose
      • Synthesis of phenyl 4,6-O-pyruvate acetal-1-thio-D-galactopyranosidee (11)
      • NMR based stability study
      • HPLC based stability study
      • Regioselective conjugation
    • Conclusion
    • Experimental
      • Materials and methods
      • Isolation and purification of PS A1
        • Culture of bacteria
        • Extraction of PS A1
        • Purification of PS A1
      • Synthesis of designed conjugates and model compounds
        • Tn-Thr-PS A1 conjugate
      • Stability study
        • Preparation of buffer solutions
        • NMR analysis at different temperatures
        • HPLC analysis at different temperatures
    • Disclosure statement
    • References

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