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标题:Upregulated IL-1 Receptor-associated Kinase 1 (IRAK1) in Systemic Lupus Erythematosus: IRAK1 Inhibition Represses Th17 Differentiation with Therapeutic Potential.
时间:2020-02-15 09:52:20
DOI:10.1080/08820139.2018.1458105
PMID:29611775
作者:Zhou, Zhou; Tian, Zhiqiang; Zhang, Mengjie
出版源: 《Immunological Investigations》 :1-16
大小:2340 kb
页数:18 PAGES
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目录:
  • Abstract
  • Introduction
  • Materials and methods
    • Ethics
    • Patients
    • Cell isolation and purification
    • Cell cultures
    • Quantitative reverse transcription-polymerase chain reaction (qRT-PCR)
    • Flow cytometry
    • Enzyme-linked immunosorbent assay (ELISA)
    • Western blotting
    • RNA interference
    • Statistical analysis
  • Results
    • IRAK1 is overexpressed in CD4+ T cells from SLE patients and correlates with clinical parameters
    • IL-1β enhances IRAK1 phosphorylation in CD4+ T cells from SLE patients
    • Plasma IL-17A levels and the frequency of circulating Th17 cells are increased in SLE patients and correlate positively with disease activity
    • IRAK1 expression correlates positively with circulating amounts of IL-17A and Th17 cells in SLE patients
    • IRAK1-Inh represses Th17 differentiation and IL-17A production in naïve CD4+ T cells from SLE patients
    • IRAK1-siRNA represses Th17 differentiation and IL-17A production in naïve CD4+ T cells from SLE patients
  • Discussion
  • Declaration of interest
  • Funding
  • References

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