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标题:Restoration of Tolerance in Lupus by Targeted Inhibitory Receptor Expression
时间:2020-02-15 00:38:10
DOI:10.1126/science.1105160
作者:McGaha; T. L.
关键词:Animals;Mice, Inbred C57BL;Mice;B-Lymphocytes;T-Lymphocytes;Lung;Kidney;Macrophages;Myeloid Cells;Chromatin
出版源: 《Science》 ,307 (5709) :590-593
摘要:Lupus, a multigenic autoimmune condition in which a breakdown of tolerance results in the development of autoantibodies, leads to a variety of pathologic outcomes. Despite the heterogeneity of factors influencing disease susceptibility, we demonstrate that the partial restoration of inhibitory Fc receptor (FcgammaRIIB) levels on B cells in lupus-prone mouse strains is sufficient to restore tolerance and prevent autoimmunity. FcgammaRIIB regulates a common B cell checkpoint in genetically diverse lupus-prone mouse strains, and modest changes in its expression can result in either tolerance or autoimmunity. Therefore, increasing FcgammaRIIB levels on B cells may be an effective way to treat autoimmune diseases.
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