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标题:Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects.
时间:2020-02-15 00:21:03
DOI:10.1007/s00702-016-1596-4
PMID:27491309
大小:709 kb
页数:25 PAGES
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目录:
  • Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson’s disease (PD): historical overview and future prospects
    • Abstract
    • Introduction
    • Tyrosine hydroxylase (TH), the regulatory enzyme for catecholamine (CA) biosynthesis: historical reminiscences
    • TH system with the cofactor BH4 and CA- and BH4-synthesizing enzymes: their genes, structures, and regulation
      • TH reaction system and pathway of BH4-synthesis
      • Human TH
      • Human AADC (DDC)
      • Human DBH
      • Human PNMT
      • DA-deficient mice
      • Monoamine oxidase (MAO) and catechol O-methyltransferase (COMT) for CA metabolism
    • Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-, and catecholamine (CA)-systems in Parkinson’s disease (PD)
      • Overview on PD research
      • Molecular mechanism of PD
      • Neuroinflammation in PD
      • Inherited disorder of TH- and BH4-related enzymes and movement disorders
      • Familial PD and sporadic PD
    • Therapies of PD in relation to CA-related enzymes: possible gene therapy
      • Possible development of neuroprotective drugs
      • Gene therapy using CA-synthesizing genes
    • Future prospects
    • Acknowledgments
    • References

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