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标题:Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration.
时间:2020-02-14 18:49:02
DOI:10.1016/j.joca.2016.06.022
PMID:27390028
作者:Shipin Zhang;Wern Cui Chu;Ruenn Chai Lai
关键词:Human;Mesenchymal stem cells;Exosomes;Cartilage;Osteochondral;Regeneration
出版源: 《Osteoarthritis & Cartilage》 ,2016 ,24 (12) :2135-2140
摘要:Articular cartilage injuries, often caused by trauma, have a limited potential to heal, which over time, may lead to osteoarthritis, an inflammatory and degenerative joint disease frequently associated with activity-related pain, swelling and impaired mobility. Many treatment modalities have been introduced but with limited success due to the formation of inferior fibrocartilage at the damaged... [Show full abstract]
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目录:
  • Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
    • Introduction
    • Methods
      • Preparation of MSC exosomes
      • Western blotting
      • Size determination
      • Detection of RNA
      • Animal experiments
      • Gross appearance and histological evaluation
      • Statistical analysis
    • Results
      • Characterization of MSC exosomes
      • Effect of MSC exosomes on repair of full-thickness cartilage defects
    • Discussion
    • Author contributions
    • Competing interests
    • Role of the funding source
    • Acknowledgement
    • Appendix A. Supplementary data
    • References

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