在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Semi-mechanistic pharmacokinetic-pharmacodynamic modelling of antibiotic drug combinations.
时间:2020-02-14 17:43:35
DOI:10.1016/j.cmi.2017.11.023
PMID:29229429
作者:Brill, Margreke J.E.; Kristoffersson, Anders N.; Zhao, Chenyan
出版源: 《Clinical Microbiology & Infection》 :S1198743X17306705
摘要:Semi-mechanistic PKPD models allow for integration of knowledge on the interaction between antibiotics for various PK and PD profiles, and can account for associated variability within the population as well as parameter uncertainty. Decisions on suitable combination regimens can thereby be facilitated. We find the application of semi-mechanistic PKPD models to be essential for efficient development of antibiotic combination regimens that optimize bacterial killing and/or suppress resistance development.
大小:1375 kb
页数:11 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Semi-mechanistic pharmacokinetic–pharmacodynamic modelling of antibiotic drug combinations
    • Introduction
    • Semi-mechanistic antibiotic PKPD modelling
    • Antibiotic combination experiments
    • Antibiotic interaction in semi-mechanistic PKPD-models
      • Model structures of antibiotic combinations
      • Interaction functions for antibiotic combinations
    • How to determine dosing regimens and study designs?
    • Discussion and implications
    • Transparency declaration
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系