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标题:Nanoparticle albumin bound-paclitaxel for treatment of advanced non-small cell lung cancer: an evaluation of the clinical evidence.
时间:2020-01-15 20:15:20
DOI:10.1080/14656566.2018.1546290
PMID:30439289
作者:Diego Adrianzen Herrera;Nadia Ashai;Roman Perez-Soler
出版源: Expert Opinion on Pharmacotherapy ,2018 (10) :1-8
大小:1031 kb
页数:10 PAGES
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目录:
  • Abstract
  • 1. Introduction
  • 2. Basics of nab-paclitaxel
    • 2.1. Chemistry
    • 2.2. Pharmacodynamics
    • 2.3. Pharmacokinetics
  • 3. Therapeutic effect in NSCLC
    • 3.1. Dose determination trials
    • 3.2. Clinical effects in first-line setting as single agent
    • 3.3. Clinical effects at first-line setting in combination
      • 3.3.1. First-line combination with carboplatin
      • 3.3.2. Other first-line combinations and comparison including immunotherapy
    • 3.4. Clinical effect atsecond or above lines for refractory disease
    • 3.5. Safety and tolerability
  • 4. Regulatory affairs
  • 5. Potential populations with special benefits
    • 5.1. The elderly
    • 5.2. Squamous histology
    • 5.3. Peripheral neuropathy
    • 5.4. Common medical comorbidities
  • 6. Biomarkers
  • 7. Expert opinion
  • Funding
  • Declaration of interest
  • Reviewer disclosures
  • References

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