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标题:Analgesic effects of TLR4/NF-κB signaling pathway inhibition on chronic neuropathic pain in rats following chronic constriction injury of the sciatic nerve.
时间:2020-01-14 22:27:03
DOI:10.1016/j.biopha.2018.07.116
PMID:30114636
作者:Xu Longhe; Liu Yaobo; Sun Yuhui
出版源: Biomedicine & Pharmacotherapy ,2018
大小:2047 kb
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目录:
  • Analgesic effects of TLR4/NF-κB signaling pathway inhibition on chronic neuropathic pain in rats following chronic constriction injury of the sciatic nerve
    • Introduction
    • Materials and methods
      • Ethics statement
      • Experimental animals and animal grouping
      • Model establishment
      • Intrathecal administration
      • Measurement of mechanical withdrawal threshold (MWT)
      • Measurement of thermal withdrawal latency (TWL)
      • Tissue collection
      • Reverse transcription quantitative polymerase chain reaction (RT-qPCR)
      • Western blot analysis
      • Immunohistochemistry
      • Statistical analysis
    • Results
      • The rat models are successfully established
      • The inhibition of TLR4/NF-κB signaling pathway increases MWT values
      • The inhibition of TLR4/NF-κB signaling pathway increases TWL values
      • The inhibition of TLR4/NF-κB signaling pathway reduces the expressions of TLR4, NF-κB, GDNF, GFAP and NGF
      • GFAP, NGF and GDNF are reduced by the inhibition of TLR4/NF-κB signaling pathway
    • Discussion
    • Conclusion
    • Competing interests
    • Acknowledgments
    • References

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