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标题:Folic acid deficiency and vision: a review.
时间:2020-01-14 19:46:30
DOI:10.1007/s00417-019-04304-3
PMID:30919078
作者:Ouafa;Sijilmassi
关键词:Eye;disease;Folate;receptors;Folic;acid;deficiency
摘要:Folic acid (FA), also termed folate, is an essential vitamin for health at all ages since it participates in the biosynthesis of nucleotides, amino acids, neurotransmitters, and certain vitamins. It is therefore crucial for rapidly growing tissues such as those of the fetus. It is becoming clear that FA deficiency and impaired folate pathways are implicated in many diseases of both early life and old age. FA can be transported into the cell by the folate receptor, the reduced folate transporter, and proton-coupled folate transporter. Folate transport proteins are present in certain eye tissues, which explains why FA plays an important role in eye development. The purpose of this literature review is to investigate the evidence relating FA deficiency to eye diseases.
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目录:
  • Folic acid deficiency and vision: a review
    • Abstract
    • Introduction
    • A brief description of human eye development
    • Folate transport proteins and their localization in ocular structure
    • Folic acid deficiency and ocular disease
      • FA deficiency in patients
      • FA deficiency in animal models
    • Conclusion
    • References

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