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标题:Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
时间:2019-12-04 00:30:58
DOI:10.1016/j.nbd.2014.12.015
PMID:25549873
大小:1580 kb
页数:14 PAGES
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目录:
  • Effective termination of status epilepticus by rational polypharmacy in the lithium–pilocarpine model in rats: Window of op...
    • Introduction
    • Materials and methods
      • Animals
      • Electrode implantation and SE induction
      • Termination of SE
      • Video–EEG monitoring
      • Behavioral experiments and seizure threshold determination
      • Assessment of neurodegeneration in the hippocampal formation
      • Drugs
      • Statistics
    • Results
      • Efficacy of different treatment protocols to terminate SE
      • Seizures in the first week after SE
      • Development of late, unprovoked seizures
      • Alterations in behavior and seizure threshold during the latent period
      • Neurodegenerative alterations in the hippocampal formation
      • Relationship between early seizures, hilar damage and occurrence of late seizures
    • Discussion
    • Acknowledgments
    • References

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