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标题:Diagnostic value of circulating microRNA-27a/b in patients with acute pulmonary embolism
时间:2019-12-03 19:11:50
DOI:10.23736/S0392-9590.17.03877-9
作者:Qian Wang;Junfen Ma;Zhiyun Jiang
出版源: 《International Angiology A Journal of the Inter... ,2017 ,37 (1)
摘要:Abstract Background: Circulating microRNAs (miRNAs) have been increasingly suggested as biomarkers for numerous diseases. The aims of this study were to evaluate the expression of plasma miR-27a/b in patients with acute pulmonary embolism (APE) and determine the possibility of miR-27a/b as diagnostic biomarkers for APE. Methods: 78 APE patients diagnosed by computed tomographic pulmonary angiography (CTPA) and 70 age and gender matched normal volunteers were included in this study. The levels of miR-27a and miR-27b were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and the concentrations of plasma D-dimer were measured using immunoturbidimetric assay. Results: The levels of plasma miR-27a and miR-27b were significantly higher in APE patients (P < 0.001) compared with normal controls. Receiver operating characteristic (ROC) curve analyses showed that plasma miR-27a was superior to miR-27b for the diagnosis of APE (AUC = 0.784, AUC = 0.707, respectively). Combining miR-27a or miR-27b with D-dimer significantly increased the diagnostic capacity of APE. Conclusions: Our results showed that circulating miR-27a and miR-27b might be potential novel diagnostic biomarkers in APE patients.
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