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标题:Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease.
时间:2019-12-03 09:35:48
DOI:10.1016/j.yfrne.2012.07.001
PMID:22796576
作者:Eyles, Darryl W.; Burne, Thomas H.J.; McGrath, John J.
关键词:Vitamin D; Brain; Development; Degeneration; Neurosteroid; Vitamin D deficiency; Neuroprotection; Psychiatric disease
出版源: 《Frontiers in Neuroendocrinology》 ,34 (1) :47-64
摘要:Increasingly vitamin D deficiency is being associated with a number of psychiatric conditions. In particular for disorders with a developmental basis, such as autistic spectrum disorder and schizophrenia the neurobiological plausibility of this association is strengthened by the preclinical data indicating vitamin D deficiency in early life affects neuronal differentiation, axonal connectivity, dopamine ontogeny and brain structure and function. More recently epidemiological associations have been made between low vitamin D and psychiatric disorders not typically associated with abnormalities in brain development such as depression and Alzheimer's disease. Once again the preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link. In this review we have attempted to integrate this clinical epidemiology with potential vitamin D-mediated basic mechanisms. Throughout the review we have highlighted areas where we think future research should focus. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
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目录:
  • Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
    • 1 Introduction
    • 2 Vitamin D metabolism
      • 2.1 Evidence for Vitamin D metabolism and catabolism in brain
    • 3 The vitamin D receptor (VDR) in developing and mature brain
      • 3.1 Vitamin D is a neuroactive steroid
      • 3.2 Is the VDR in brain?
      • 3.3 VDR and non-neuronal cells
      • 3.4 VDR in the developing brain
      • 3.5 Nongenomic vitamin D signaling
    • 4 Vitamin D and the developing brain; in vivo studies
      • 4.1 DVD-deficiency
      • 4.2 Persistent effects of DVD-deficiency on the adult brain
      • 4.3 DVD-deficiency and neurotransmitters
        • 4.3.1 DVD deficiency and dopamine
      • 4.4 The impact of DVD-deficiency on adult behavior
      • 4.5 The DVD-deficient mouse
      • 4.6 Inducing vitamin D deficiency by genetically modifying vitamin D signaling
    • 5 Vitamin D alters neurotransmitter expression in adult brain
    • 6 What are the mechanisms linking vitamin D with brain development and function?
      • 6.1 Vitamin D is a potent differentiation agent for brain cells
      • 6.2 Vitamin D and axonal growth
      • 6.3 Vitamin D down-regulates voltage sensitive L-type calcium channels
      • 6.4 Regulation of reactive oxygen species
      • 6.5 Regulation of neurotrophic factors
    • 7 Vitamin D and neuropsychiatric disorders
      • 7.1 Vitamin D and schizophrenia
      • 7.2 Vitamin D and autism
      • 7.3 Vitamin D and depression
      • 7.4 Vitamin D, cognition and dementia
    • 8 Future directions
      • 8.1 What is the optimal vitamin D concentration for brain-related outcomes
      • 8.2 Is the association between vitamin D concentration and disease outcomes non-linear?
      • 8.3 Refining research techniques to explore the timing of vitamin D exposures and brain-related outcomes
    • 9 Conclusions
    • Conflict of interest
    • Acknowledgments
    • References

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