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标题:Absolute bioavailability of digoxin tablets
时间:2019-12-03 08:45:34
DOI:10.1002/ardp.19783111212
作者:T, Beveridge;E, Nüesch;E E, Ohnhaus
关键词:Humans;Digoxin;Tablets;Administration, Oral;Injections, Intravenous;Biological Availability;Kinetics;Adult;Male
摘要:Ten healthy male volunteers each received 0.5 mg digoxin orally and i.v. in a randomised, cross-over sequence with at least two weeks between doses. Plasma concentration and cumulative urinary excretion of digoxin were measured up to 6 and 144 h, respectively, after administration using a radioimmunoassay method. Absolute bioavailability (i.e. the percentage absorption from tablets compared to i.v. injection) was calculated by four methods: by comparing areas under plasma concentration/time curves (AUC) up to 6 h and to infinity, also by comparing cumulative urinary excretion up to 144 h (t max.) and to infinity. The mean of the two extrapolated values for the absolute bioavailability of digoxin (Sandoz) tablets is 78%.
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