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标题:Asymmetric Brønsted Acid Catalyzed Substitution of Diaryl Methanols with Thiols and Alcohols for the Synthesis of Chiral Thioethers and Ethers.
时间:2019-12-03 08:27:02
DOI:10.1002/anie.201511179
PMID:26952288
作者:Chatupheeraphat, Adisak; Liao, Hsuan-Hung; Mader, Steffen
关键词:Brønsted acids;carbenium ions;Michael addition;ortho-quinone methides;substitution
出版源: 《Angew Chem Int Ed Engl》 ,55 (15) :4803-4807
摘要:Abstract An enantioselective addition of thiols and alcohols to aza- ortho -quinone methides, starting from diaryl methanols, was developed. The asymmetric additions occur under mild reaction conditions in the presence of chiral phosphoric acids and furnish the corresponding adducts with excellent yields and enantioselectivities.
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