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标题:Asymmetric Brønsted Acid Catalyzed Synthesis of Triarylmethanes-Construction of Communesin and Spiroindoline Scaffolds
时间:2019-12-03 08:22:24
DOI:10.1002/anie.201505981
作者:Liao, Hsuan-Hung; Chatupheeraphat, Adisak; Hsiao, Chien-Chi
关键词:indole derivatives, isoindole derivatives;spirocyclic compounds (heterocyclic compounds;fused pyridine derivatives;C‐C bond formation;organocatalysis;ring closure reactions, annulation reactions;diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism
出版源: 《Angewandte Chemie International Edition》 ,54 (51) :15540-15544
摘要:Abstract Aza- ortho -quinone methides allow the straightforward asymmetric synthesis of natural-product-inspired indole scaffolds possessing a quaternary stereocenter. Our approach provides access to diverse communesin and spiroindoline derivatives with high enantioselectivity under mild reaction conditions. Predictable substitution patterns are found to be the key to our regiodivergent protocols.
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