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标题:Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accessed by a Palladium-Catalyzed Enantioselective Alkene Difunctionalization Reaction
时间:2019-12-03 08:12:51
DOI:10.1021/ja103472a
作者:Pathak, Tejas P.; Gligorich, Keith M.; Welm, Bryan E.
出版源: Journal of the American Chemical Society ,2010
摘要:A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
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