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标题:Organoids: An intermediate modeling platform in precision oncology.
时间:2019-11-20 01:33:37
DOI:10.1016/j.canlet.2017.11.021
PMID:29174804
作者:Jin, Ming-Zhu; Han, Run-Run; Qiu, Guan-Zhong
出版源: Cancer Letters ,414 :174-180
摘要:Cancer harbors variable heterogeneity and plasticity. Thus far, our comprehension is greatly based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids are a three-dimensional in vitro culture platform constructed from self-organizing stem cells. They can almost accurately recapitulate tumor heterogeneity and microenvironment "in a dish," which surpass established cell lines and are not as expensive and time-consuming as PDTXs. As an intermediate model, tumor organoids are also used to study the fundamental issues of tumorigenesis and metastasis. They are specifically applied for drug testing and stored as "living biobanks." In this review, we highlight the translational applications of organoid technologies in tumor research and precision medicine, discuss the advantages and limitations compared with other mentioned methods, and provide our outlook on its future
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目录:
  • Organoids: An intermediate modeling platform in precision oncology
    • 1. Introduction
    • 2. Translational applications in cancer
      • 2.1. Resources and methods
      • 2.2. Disease modeling
        • 2.2.1. Organoids maintain cancer heterogeneity in culture
        • 2.2.2. Organoids recapitulate cancer hypoxia microenvironment
        • 2.2.3. Organoids mimic cancer oncogenesis and metastasis
        • 2.2.4. Gene editing system helps organoids to model diseases
      • 2.3. Drug screening and precision medicine
      • 2.4. Organoid biobanks
    • 3. Advantages and limitations vs cell lines and PDTXs
    • 4. Outlook and conclusions
    • Conflicts of interest
    • Acknowledgements
    • References

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