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标题:The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors.
时间:2019-11-19 21:15:23
DOI:10.1016/j.immuni.2012.11.013
PMID:23438823
作者:Versteeg, Gijs?A.; Rajsbaum, Ricardo; Sánchez-Aparicio, Maria?Teresa
关键词:E3 UBIQUITIN LIGASE;RIG-I;ANTIVIRAL RESPONSE;SPLICE VARIANT;NS1;PROTEIN;MOTIF;CELLS;ACTIVATION;EXPRESSION
出版源: Immunity ,38 (2) :384-398
摘要:► Nearly half of all 75 TRIM protein family members are innate immune enhancers ► TRIM mRNA expression and protein localization are complexly regulated during infection ► TRIMs confer differential regulation in distinct innate immune signaling pathways
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页数:16 PAGES
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目录:
  • The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors
    • Introduction
    • Results
      • TRIM Splice Forms Lack Key Domains
      • A Large Proportion of TRIMs Is Turned Over by the Proteasome
      • A Screening System to Identify Activators and Enhancers of Innate Immunity
      • A Large Number of TRIMs Enhances Innate Immune Responses
      • Most TRIMs Are Innate Immune Enhancers Rather Than Direct Activators
      • TRIM-Enhanced Innate Immune Signaling Confers Antiviral Cytokine Production
      • TRIM Proteins Are Regulated at the Transcriptional and Posttranscriptional Level
      • Attenuated TRIM Expression in Kidney and Lung Cell Lines Decreases IFN Induction
      • Attenuated TRIM Expression in Primary MDDCs Reduces LPS-Mediated Cytokine Expression
      • TRIM Proteins Regulate Innate Immune Signaling Originating from Different PRRs
    • Discussion
    • Experimental Procedures
      • Isolation, Transduction, and Stimulation of MDDCs
      • Cell Lines with Stable Attenuation of Gene Expression
      • IFN Antiviral Activity Assay by VSV-GFP Infection
    • Supplemental Information
    • Acknowledgments
    • References

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