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标题:Aortic arch calcification and risk of cardiovascular or all-cause and mortality in dialysis patients: A meta-analysis.
时间:2019-11-19 20:32:44
DOI:10.1038/srep35375
PMID:27748417
作者:Zhang, Ao; Wang, Shiji; Li, Hongxiang
出版源: Scientific Reports ,6 :35375
摘要:Studies on aortic arch calcification (AAC) and mortality risk in maintenance dialysis patients have yielded conflicting findings. We conducted this meta-analysis to investigate the association between the presence of AAC and cardiovascular or all-cause and mortality risk in maintenance dialysis patients. Observational studies evaluating baseline AAC and cardiovascular or all-cause mortality risk in maintenance dialysis patients were searched through the PubMed and Embase, CNKI, VIP and Wanfang databases until January 2016. A total of 8 studies with 3,256 dialysis patients were identified. Compared with patients without AAC, the presence of AAC was associated with greater risk of cardiovascular mortality (hazard risk [HR] 2.30; 95% confidence intervals [CI] 1.78–2.97) and all-cause mortality (HR 1.44; 95% CI 1.19–1.75). Subgroup analyses indicated that the pooled HR for cardiovascular and all-cause mortality was 2.31 (95% CI 1.57–3.40) and 1.45 (95% CI 1.08–1.96) for the grade 2/3 AAC. Peritoneal dialysis patients with AAC had greater cardiovascular (HR 3.93vs.HR 2.10) and all-cause mortality (HR 2.36 vs. HR 1.33) than hemodialysis patients. The AAC appears to be independently associated with excessive cardiovascular and all-cause mortality in maintenance dialysis patients. Regular follow-up AAC might be helpful to stratify mortality risk in dialysis patients.
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目录:
  • Aortic arch calcification and risk of cardiovascular or all-cause and mortality in dialysis patients: A meta-analysis
    • Results
      • Selected studies and characteristics.
      • All-cause and cardiovascular mortality.
      • Subgroup analyses and sensitivity analyses.
      • Publication bias.
    • Discussion
    • Methods
      • Search strategy.
      • Selection criteria.
      • Data extraction and quality assessment.
      • Statistical analysis.
    • Author Contributions
    • Figure 1.  Flow chart of the study selection process.
    • Figure 2.  Forest plots showing HR and 95% CI of all-cause mortality compared with and without aortic arch calcification in a random effect model.
    • Figure 3.  Forest plots showing HR and 95% CI of cardiovascular mortality compared with and without aortic arch calcification in a fixed-effect model.
    • Figure 4.  Funnel plot showing publication bias based on the all-cause mortality (A) and cardiovascular mortality (B).
    • Table 1.  Baseline characteristics of the included studies.
    • Table 2.  Subgroup analyses of all-cause and cardiovascular mortality.

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