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标题:Pathogenesis of epileptic seizures and epilepsy after stroke
时间:2019-11-17 17:21:32
DOI:10.1080/01616412.2018.1455014
作者:Yang, Huajun; Rajah, Gary; Guo, Anchen
出版源: Neurological Research :1-7
摘要:Following stroke, acute symptomatic seizures (manifestation within seven days) and epilepsy, i.e. occurrence of at least one unprovoked seizure (manifestation after more than seven days), are reported in 3–6% and up to 12% of patients, respectively. Incidence of acute symptomatic seizures is higher in intracranial haemorrhage (10–16%) than in ischaemic stroke (2–4%). Acute symptomatic seizures... [Show full abstract]
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目录:
  • Abstract
  • 1. Pathogenesis of early epileptic seizures
    • 1.1. Electrophysiological instability
    • 1.2. Neurotransmitter imbalance
  • 2. Pathogenesis of late epileptic seizures
    • 2.1. Genetic and epigenetic factors
    • 2.2. Destruction of the integrity of neurovascular units
      • 2.2.1. Change in regional cerebral blood flow (rCBF)
      • 2.2.2. Disruption of the integrity of the blood brain barrier (BBB)
      • 2.2.3. Inflammation
    • 2.3. Change in neural networks
    • 2.4. Post-stroke gliocyte proliferation
  • 3. New sight for medications of post-stroke epilepsy
  • 4. Perspective
  • Disclosure statement
  • Funding
  • Notes on contributors
  • References

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