在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Tumor metabolism, cancer cell transporters, and microenvironmental resistance.
时间:2019-11-16 21:29:02
DOI:10.3109/14756366.2016.1140753
PMID:26864256
作者:Alfarouk; Khalid O.
出版源: 《Journal of Enzyme Inhibition & Medicinal Chemi... :1-8
摘要:ABSTRACT Cancer cells reprogram their metabolic machineries to enter into permanent glycolytic pathways. The full reason for such reprogramming takes place is unclear. However, this metabolic switch is not made in vain for the lactate that is generated and exported outside cells is reused by other cells. This results in the generation of a pH gradient between the low extracellular pH that is acidic (pHe) and the higher cytosolic alkaline or near neutral pH (pHi) environments that are tightly regulated by the overexpression of several pumps and ion channels (e.g. NHE-1, MCT-1, V-ATPase, CA9, and CA12). The generation of this unique pH gradient serves as a determining factor in defining “tumor fitness”. Tumor fitness is the capacity of the tumor to invade and metastasize due to its ability to reduce the efficiency of the immune system and confer resistance to chemotherapy. In this article, we highlight the importance of tumor microenvironment in mediating the failure of chemotherapeutic agents.
大小:722 kb
页数:10 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Tumor metabolism, cancer cell transporters, and microenvironmental resistance
    • Causes of metabolic transformation
    • Monocarboxylate transporter 1 (MCT-1)
    • Vacuolar ATPase (V-ATPase)
    • Resistance
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系