在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B
时间:2019-11-16 14:32:32
DOI:10.1080/10715762.2019.1610563
作者:Chang Jia;Jian Zhang;Yingzhi Zhuge
出版源: Free Radical Research ,2019 ,53 (2) :1-11
大小:2620 kb
页数:13 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Abstract
    • Introduction
    • Materials and methods
      • Isolates
      • Antifungal susceptibility test
      • RNA isolation and quantitative real-time PCR
      • ROS determination
      • Measurement of mitochondrial membrane potential
      • Cell membrane integrity analysis
      • Nuclear division assay
      • Measurement of GSH levels, CAT, and SOD activity
      • Statistical analysis
    • Results
      • Synergistic effect of fluconazole and GdA on growth and survival in resistant C. tropicalis
      • Effect of fluconazole combined with GdA on drug efflux pumps
      • ROS levels under fluconazole plus GdA treatment
      • Combination of fluconazole with GdA affected mitochondrial membrane potential
      • Fluconazole plus GdA disrupted cell membrane integrity
      • Fluconazole combined with GdA led to the multinucleated phenotype
      • ROS scavenging rescued fluconazole plus GdA-induced defective growth
      • Effect of fluconazole plus GdA on antioxidant system
    • Discussion
    • Acknowledgements
    • Disclosure statement
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系