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标题:Electrogenic Na+/Ca2+-exchange of nerve and muscle cells.
时间:2019-11-09 20:31:51
DOI:10.1016/j.pneurobio.2007.06.003
PMID:17673353
大小:1316 kb
页数:62 PAGES
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目录:
  • Electrogenic Na+/Ca2+-exchange of nerve and muscle cells
    • Introduction
    • Stoichiometry and voltage-sensitivity of Na+/Ca2+-exchange
      • Regulation of Na+/Ca2+-exchange
        • Transported ions; Ca2+-efflux-(normal)-mode
        • Transported ions; Ca2+-influx-(reverse)-mode
      • Non-transported ions; intracellular Na+
      • Non-transported ions; intracellular Ca2+
      • External monovalent cations
      • Na+-Ca2+-competiton
      • ATPi-activation
      • pH-dependence
      • Temperature-dependence
    • Inward and outward Na+/Ca2+-exchange currents under physiological and pathological conditions
    • Number of Na+/Ca2+-exchange molecules (density of exchanger)
    • Turnover rate of Na+/Ca2+-exchange and other ion transporters
    • Reversal potential (ENa/Ca) and driving force (ΔVNa/Ca) of Na+/Ca2+-exchange
    • Pharmacology of Na+/Ca2+-exchange; putative inhibitors
      • Inorganic ions
        • Transition heavy metals
        • Alkali earth metals
      • Organic inhibitors
        • Amiloride and its derivatives (benzamil, 3′,4′-dichlorobenzamil)
        • Other organic compounds (phenylalkylamines, aminoglycosides, KB-R7943, SE0400, SN-6)
        • Exchanger inhibitory peptide (XIP)
    • Tetrodotoxin-sensitive Na+-influx-induced outward Na+/Ca2+-exchange current contributes to [Ca2+]i-transient and SR Ca2+-release (CICR) when ICa(L) is blocked
    • Na+-pump and Na+/Ca2+-exchange
      • Co-localisation and functional interaction of Na+-pump and Na+/Ca2+-exchange
      • Na+-pump like region of the exchanger
      • Therapeutic effect of cardiac glycosides
        • Nanomolar concentrations of cardiac glycosides
        • Some interesting and unexpected observations
      • Expression and function of Na+/Ca2+-exchanger and other ion transporters under patho-physiological conditions
        • Slow Na+-channel, β-receptor and ‘‘L-type’’ Ca2+-channel
        • Na+-pump (Na+,K+-ATPase)
        • Na+/Ca2+-exchanger
        • Sarcoplasmic reticulum (SR) Ca2+-ATPase
        • Repolarising K+-channels
    • High voltage-activated Ca2+-channels involved in neurotransmitter release
      • Inhibition of VSCCs and transmitter release by activation of presynaptic α2-receptors
    • Na+-pump and Na+/Ca2+-exchange regulation by adrenoceptors
      • Reverse Na+/Ca2+-exchange and transmitter release regulation by pre-synaptic α2-adrenoceptors
    • Conclusions
    • Acknowledgements
    • References

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