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标题:Excitotoxicity: bridge to various triggers in neurodegenerative disorders.
时间:2019-11-09 20:23:11
DOI:10.1016/j.ejphar.2012.10.032
PMID:23123057
大小:1194 kb
页数:14 PAGES
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目录:
  • Excitotoxicity: Bridge to various triggers in neurodegenerative disorders
    • Introduction
    • History of glutamate
    • Glutamate--a neurotransmitter
    • Glutamate actions in brain
    • Glutamate receptors
    • Brain self destruction machinery
    • Pathogenesis of neurodegenerative disorders
    • Various triggering events for glutamatergic system excitotoxicity
      • Calcium mediated excitotoxicity and mitochondrial dysfunction
      • Free radicals and excitotoxicity
      • Involvement of NO and other reactive nitrogen species
      • Chloride homeostasis and excitotoxicity
      • Depolarization of GABAergic neurons--A gate to plasticity and excitotoxicity
      • Slow excitotoxic trigger and metabolic impairment
      • Role of COX, LOX and EPOX in excitotoxic injury
      • Relationship between excitotoxicity and apoptosis
      • Overactivation of glutamate in CNS disorders
      • Synaptic vs extrasynaptic localization of NMDA receptors and excitotoxicity
    • Recent pharmacological findings to combat glutamate excitotoxicity
    • Recent strategies to combat glutamate excitotoxicity
    • Future directions
    • Conclusion
    • References

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