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标题:Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin.
时间:2019-11-09 19:11:08
DOI:10.1016/j.ijpharm.2005.12.043
PMID:16457972
大小:280 kb
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目录:
  • Characterization and cytotoxicity of mixed polyethyleneglycol modified liposomes containing doxorubicin
    • Introduction
    • Materials and methods
      • Materials
      • Determination of the octanol/water value and the critical micelle concentration (c.m.c.) value of the PEG-CHO lipids
      • Preparation of the PEG-CHO incorporating liposomes
      • Physicochemical characteristics of liposomes
      • Determination of the incorporated ratio of PEG-CHOs using the picrate method
      • Residual PEG-CHOs on liposomal membranes
      • Determination of the encapsulation efficiency of DOX
      • Effects of PEG-CHO modification on the DOX uptake into tumor cells
      • Effects of PEG-CHO modification on DOX cytotoxicity
      • Statistical analysis
    • Results
      • Octanol/water value and c.m.c. of PEG-CHO lipids
      • Particle size and FALT of PEG-CHO modified liposomes
      • Incorporated ratio and residual amount of PEG-CHOs in liposome
      • Effect of mixed PEG-CHO modification on DOX uptake by Ehrlich ascites carcinoma cells
      • Cytotoxicity of mixed PEG-CHO modified liposomes containing DOX on Ehrlich ascites carcinoma cells and P388 leukemia cells
    • Discussion
    • Conclusion
    • Acknowledgement
    • References

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