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标题:The cis-regulatory dynamics of embryonic development at single-cell resolution
时间:2019-11-09 11:45:23
大小:27559 kb
页数:23 PAGES
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目录:
  • The cis-regulatory dynamics of embryonic development at single-cell resolution
    • Authors
    • Abstract
    • References
    • Acknowledgements
    • Author Contributions
    • Figure 1 Single-cell profiling of chromatin accessibility across Drosophila embryogenesis.
    • Figure 2 Temporal dynamics and spatial heterogeneity in chromatin accessibility in the early embryo.
    • Figure 3 Single cells are readily assigned to tissues and cell types based on chromatin accessibility.
    • Figure 4 Prediction of tissue-specific enhancer activity using sci-ATAC-seq.
    • Extended Data Figure 1 Summary of read distributions across the three sampled time points.
    • Extended Data Figure 2 Enhancer enrichments for LSI clades at 6–8 h and 10–12 h.
    • Extended Data Figure 3 Relationship between transcription-factor binding motifs and occupancy, and LSI clade-specific accessibility.
    • Extended Data Figure 4 Similarities and differences in accessibility across all three time points.
    • Extended Data Figure 5 Sex of individual cells identified by ratio of X-chromosome to autosomal reads.
    • Extended Data Figure 6 Temporal ordering of cells at 2–4 h using Monocle.
    • Extended Data Figure 7 Library complexity and fraction of X chromosome reads highlights clusters of collisions between cells from different tissues.
    • Extended Data Figure 8 LSI-defined clades and t-SNE clusters show strong correspondence.
    • Extended Data Figure 9 Cell cluster assignment is similar using either enhancer or gene tissue activity.
    • Extended Data Figure 10 sci-ATAC-seq can predict tissue-specific enhancer usage during development.

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