在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxid...
时间:2019-11-08 22:37:04
大小:1567 kb
页数:13 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase
    • Abstract
    • Introduction
    • Materials and methods
      • Patients and sampling
      • Definition of infection
      • Monocyte phagocytosis and oxidative burst assays
      • Monocyte isolation
      • Monocyte superoxide production
      • Bacterial killing assay
      • IFN-Γ and prednisolone co-culture
      • Western blotting of monocyte G6PDH, pSTAT-1, SOCS-1, gp91phox and p47phox proteins
      • Paired longitudinal samples
      • Statistical analysis
    • Results
      • Patient characteristics
      • Phagocytosis of whole bacteria is preserved in SAH
      • MOB and bacterial killing are impaired in SAH
      • Defective MOB is associated with increased risk of developing infection
      • MOB defect increases susceptibility to catalase-positive organisms
      • In vivo prednisolone therapy does not depress MOB
      • Mechanism of MOB defect
      • Nicotinamide adenine dinucleotide phosphate substrate provision
      • Diminished NADPH oxidase expression in monocytes with MOB defect
      • SAH monocytes are refractory to IFN-Γ, which may be explained by elevated SOCS-1 protein
    • Discussion
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系