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标题:Engineering of chaperone systems and of the unfolded protein response
时间:2019-10-23 17:10:28
DOI:10.1007/s10616-008-9157-9
大小:731 kb
页数:26 PAGES
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目录:
  • Engineering of chaperone systems and of the unfolded protein response
    • Abstract
    • Introduction
    • The rate- and yield limiting step for heterologous protein production
    • The ER-resident protein folding machinery
      • ER-resident molecular chaperone systems
        • BiP and Lhs1p?HSP70 chaperones of the ER
        • GRP94?an HSP90 chaperone of the ER
        • The lectin chaperones calnexin, calreticulin, and calmegin
      • Oxidative protein folding in the ER
      • ERAD and autophagy
    • The unfolded protein response
      • Signal transduction mechanisms in the UPR
      • Physiological responses regulated by the UPR
        • Induction of molecular chaperones and foldases
        • Stimulation of phospholipid synthesis
        • ERAD and autophagy
        • Attenuation of protein synthesis
        • Antioxidant response
        • Apoptotic response to ER stress
        • Activation of immune and inflammatory responses
    • Cell engineering of the early secretory pathway
      • Engineering of the ER-resident protein folding machinery
    • Engineering of the UPR
    • Conclusions
    • Acknowledgements
    • References

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