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标题:Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone.
时间:2019-10-23 16:53:07
DOI:10.1007/s11095-011-0470-1
PMID:21614636
大小:557 kb
页数:13 PAGES
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目录:
  • Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • INTRODUCTION
    • MATERIALS AND METHODS
      • Materials
      • PEG-PBLA Block Copolymer Synthesis
      • PEG-p(Asp-Est-Dex) Synthesis
      • PEG-p(Asp-Hyd-DEX) Synthesis
      • PEG-p(Asp-Hyd-X-Est-DEX) Synthesis (‘X’ Indicates Ketonic Acids as Spacers)
      • Polymer Micelle Preparation
      • Analytical Methods
      • pH-Dependent Drug Release Study
      • Carboxylesterase-Dependent Drug Release Study
      • Statistics
    • RESULTS
      • Block Copolymer Synthesis
      • Polymer Micelle Preparation
      • pH-Dependent DEX Release from the Micelles
      • Carboxylesterase-Dependent Drug Release
    • DISCUSSION
      • Polymer Synthesis and DEX Conjugation
      • Preparation of DEX-Loaded Micelles
      • pH-Dependent DEX Release from the Micelles
      • Tunable DEX Release from the Micelles
      • Enzymatic Stability of DEX-Loaded Micelles
    • CONCLUSION
    • REFERENCES

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