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标题:Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats.
时间:2019-10-10 17:04:58
DOI:10.1007/s12035-017-0636-x
PMID:28585189
大小:5341 kb
页数:13 PAGES
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目录:
  • Modulatory...
    • Abstract
    • Introduction
    • Materials and Methods
      • Animals
      • Chemicals and Drugs
      • Experimental Design
      • Behavioral Assessment
      • Open Field
      • Rotarod
      • Brain Processing
      • Measured Parameters
      • Enzyme Linked Immunosorbent Assay of Levels of DA in the Striatum as well as NF-кB, TNF-α, and TAT in the SN
      • Quantitative Real-Time Polymerase Chain Reaction Analysis of α-Synuclein, Nurr1, TH, VMAT, GDNF, and CoREST Gene Expression in the SN
      • Western Blot Analysis of c-Ret Protein Expression in the SN
      • Histopathological Examination
      • Statistical Analysis
    • Results
      • DE-Amended Behavioral Changes Induced by Rotenone
      • DE-Reversed Rotenone-Induced Alterations in Striatal DA Level and α-Synuclein Gene Expression in SN
      • DE-Mitigated Rotenone-Induced Alterations in Nurr1 and Nurr1-Regulated Genes
      • DE-Attenuated Rotenone-Induced Inflammatory Changes
      • DE-Alleviated Rotenone-Induced Alteration in Thrombin Generation
      • DE-Preserved Dopaminergic Neurons in SN Against Rotenone-Induced Deterioration
    • Discussion
    • References

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