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标题:The Salmonella effector protein SifA plays a dual role in virulence.
时间:2019-09-12 00:12:48
DOI:10.1038/srep12979
PMID:26268777
作者:Weidong Zhao;Thomas Moest;Yaya Zhao;AudeAgnès Guilhon;Christophe Buffat
出版源: 《Sci Rep》 ,2015 ,5 (1) :12979
摘要:Abstract The virulence of Salmonella relies on the expression of effector proteins that the bacterium injects inside infected cells. Salmonella enters eukaryotic cells and resides in a vacuolar compartment on which a number of effector p...
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目录:
  • The Salmonella effector protein SifA plays a dual role in virulence
    • Results
      • Characterization of SKIP−/− mice.
      • SKIP−/− mice are less sensitive to Salmonella infection than congenic C57BL/6.
      • Characterization of a SKIP-independent function of SifA.
      • The SKIP-independent function of SifA is associated with its C-term domain.
      • SifA and SseJ contribute independently to Salmonella Virulence.
      • The SifA C-term is important for the recruitment of LAMP1 to the SCV and for intracellular replication.
    • Discussion
    • Methods
      • Material.
      • Antibodies.
      • Mouse Strains.
      • Ethic statement.
      • Bacterial strains and growth conditions.
      • Construction of plasmids.
      • Construction of mutant strains.
      • Eukaryotic cells and culture conditions.
      • Bacterial infection and replication assays.
      • Competitive index.
      • Statistical Analyses.
    • Acknowledgments
    • Author Contributions
    • Figure 1.  Phenotyping of SKIP−/− mice.
    • Figure 2.  SKIP−/− mice are more resistant to salmonellosis than congenic C57BL/6 mice.
    • Figure 3.  The SifA C-term is accountable for the SKIP-independent function of SifA in virulence.
    • Figure 4.  SifA C-term function in infected cells.

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