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标题:Aging, frailty and complex networks.
时间:2019-09-11 23:54:32
DOI:10.1007/s10522-017-9684-x
PMID:28255823
作者:A. B. Mitnitski;A. D. Rutenberg;S. Farrell;K. Rockwood
出版源: 《Biogerontology》 ,2017 ,18 (4) :433-446
摘要:Abstract When people age their mortality rate increases exponentially, following Gompertz's law. Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses and conditions and so become increasingly vulne...
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目录:
  • Aging, frailty and complex networks
    • Abstract
    • Introduction
    • Objective
    • The model
      • General
      • A network of interacting nodes
      • Mutual information of FI and mortality
    • Discussion
      • General
      • Why do old people tend to die sooner than young people with the same FI?
      • Damage accumulation versus genetic programming
      • Relationship between model deficits and observational human health deficits
      • Informativeness of deficits depend on their connectivity degree
      • Implications of the frailty limit
      • Frailty instrument based on more deficits predict mortality better than those with fewer deficits
      • Complex networks in biomedical applications and gerontology
      • Perspectives
    • Conclusion
    • Acknowledgements
    • Authors’ contributions
    • References

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