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标题:Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.
时间:2019-09-11 22:59:09
DOI:10.1016/j.kint.2017.10.021
PMID:29373150
作者:Z Li;K Xu;N Zhang;G Amador;Y Wang
出版源: 《Kidney International》 ,2018 ,93 (4)
摘要:Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling.Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has ...
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目录:
  • Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling
    • Results
      • SIRT6 protects primary kidney epithelial cells from CP-induced apoptosis
      • Overexpressed SIRT6 attenuates CP-induced increase of blood urea nitrogen and serum creatinine
      • SIRT6 alleviates CP-induced renal tubular damage
      • SIRT6 reduces inflammation and inhibits the activity of nuclear factor-κB
      • SIRT6 decreases apoptosis and inhibits the activity of p53
      • SIRT6 inhibits the expression of ERK1/2 by deacetylating H3K9
      • Inhibition of ERK1/2 activity eliminates aggravation of kidney injury caused by SIRT6 KO
    • Discussion
    • Methods
      • Mice models
      • Cell culture
      • TUNEL assay
      • Assay for renal function and inflammatory cytokines
      • Proliferation assay
      • Quantification of mitochondrial DNA
      • Immunofluoresence staining
      • Flow cytometry
      • Quantitative reverse transcriptase PCR
      • Western blot analysis
      • Luciferase reporter analyses
      • Histology
      • Immunoprecipitation
      • Chromatin immunoprecipitation assay
      • Statistics
    • Disclosure
    • Acknowledgments
    • Supplementary Material
    • References

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