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标题:Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury.
时间:2019-09-11 22:54:43
DOI:10.1016/j.kint.2017.08.014
PMID:29061334
作者:Raup-Konsavage WM;Wang Y;Wang WW;Feliers D;Ruan H
出版源: 《Kidney International》 ,2018 ,93 (2)
摘要:Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injuryIschemia/reperfusion is a common cause of acute kidney injury (AKI). However, mechanisms underlying the sudden loss in ...
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目录:
  • Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury
    • Results
      • PAD4 is upregulated in mouse kidneys after I/R injury
      • PAD4 mediates kidney I/R injury
      • PAD4 promotes inflammation after renal I/R injury
      • PAD4 is essential for NET formation after I/R injury
      • NETs contribute to renal I/R injury
      • Neutrophil PAD4 is essential for renal R/I injury
    • Discussion
    • Methods
      • Acute ischemia/reperfusion injury in mice
      • Histology and immunofluorescence microscopy
      • Analysis and quantification of leukocytes and NETs
      • Neutrophil transfer
      • Assays of renal function
      • DNase I and PAD4 inhibitor treatment
      • Statistical analyses
    • Disclosure
    • Acknowledgments
    • Supplementary Material
    • References

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