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标题:Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease.
时间:2019-09-11 22:46:56
DOI:10.1016/j.kint.2018.02.026
PMID:29861060
作者:K DurlacherBetzer;A Hassan;R Levi;J Axelrod;J Silver
出版源: 《Kidney International》 ,2018 ,94 (2) :315
摘要:Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease.Abstract The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury (AKI) and ...
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目录:
  • Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease
    • Results
      • Inflammatory cytokines are increased in folic acid–induced AKI
      • Dexamethasone prevents the increase in serum FGF23 in AKI
      • IL-6 knock out mice fail to increase FGF23 expression in adenine–high-phosphorus–induced uremia
      • Hyper–IL-6 increases FGF23 levels in vivo and in vitro in calvaria organ cultures and serum sIL-6R is increased in uremia
      • Hyper–IL-6 increases FGF23 expression through STAT3 signaling
    • Discussion
    • Methods
      • In vivo studies
      • Serum biochemistry
      • Calvaria organ cultures
      • Cell cultures
      • RNA and protein extraction
      • Deletions and site-specific mutagenesis
      • Bioinformatics promoter analysis
      • Primers
      • Quantitative reverse-transcription polymerase chain reaction
      • Western blots
      • Statistics
    • Disclosure
    • Acknowledgments
    • Supplementary Material
    • References

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