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标题:Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro.
时间:2019-09-11 17:45:17
DOI:10.1016/j.fct.2017.11.015
PMID:29129665
作者:S Holzner;S Brenner;AG Atanasov;D Senfter;S Stadler
出版源: 《Food & Chemical Toxicology》 ,2017 ,111 (Article 3) :114
摘要:Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro....
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目录:
  • Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro
    • Introduction
    • Material and methods
      • Antibodies and reagents
      • Cell culture
      • Spheroid formation and drug treatment
      • CCID (circular chemorepellent induced defect) assay
      • SDS gel electrophoresis and Western blotting
      • 12(S)-HETE assay
      • Ethoxyresorufin-O-deethylase (EROD) assay selective for CYP1A1/1A2 activity
      • NF-κB transactivation assay
      • Statistical analysis
    • Results
      • Potential mechanisms of SW620 spheroid intravasation through the BEC barrier
      • Inhibition of CCID formation by clinically used drugs
      • Inhibition of CCID formation in a 5-FU-resistant SW620-R/BEC model
      • Inhibition of CCID formation by flavonoids contained in fruits and herbs
    • Discussion
    • Conflicts of interest
    • Acknowledgements
    • Transparency document
    • References

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