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标题:L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.
时间:2019-09-11 17:35:39
DOI:10.1186/1744-8069-8-7
PMID:22292988
作者:Takehiro Kawashiri;Nobuaki Egashira;Kentaro Kurobe;Kuniaki Tsutsumi;Yuji Yamashita
出版源: 《Molecular Pain》 ,2012 ,8 (1) :7
摘要:( 2012 ). L type Ca 2 + channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats . Mol Pain 8 , 1 – 10 ....
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页数:11 PAGES
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目录:
  • Abstract
    • Background
    • Methods
    • Results
    • Conclusions
  • Background
  • Methods
    • Drugs and chemicals
    • Animals
    • Behavioral test
    • Cell cultures
    • Measurement of intracellular Ca2+ level
    • Immunostaining of NFATc4
    • Reverse transcription-polymerase chain reaction (RT-PCR)
    • Western blotting
    • Statistical analyses
  • Results
    • Oxaliplatin increases cold hyperalgesia and TRPM8 expression in the DRG in rats
    • Oxaliplatin and oxalate increase the TRPM8 mRNA levels in primary cultured DRG cells
    • Oxaliplatin and oxalate increase the intracellular Ca2+ levels in primary cultured DRG cells
    • Oxaliplatin and oxalate induce NFAT nuclear translocation in primary cultured DRG cells
    • Ca2+ and Na+ channel blockers inhibit the oxalate-induced increase of TRPM8 mRNA levels in cultured DRG cells
    • Ca2+ and Na+ channel blockers inhibit the oxaliplatin-induced cold hyperalgesia and increase in TRPM8 mRNA levels in the DRG in rats
  • Discussion
  • Conclusions
  • Acknowledgements
  • Authors' contributions
  • Competing interests
  • References

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