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标题:Jumonji histone demethylases as emerging therapeutic targets.
时间:2019-08-14 23:05:50
DOI:10.1016/j.phrs.2016.01.026
PMID:26816087
作者:Sung Yeon Park;Jong-Wan Park;Yang-Sook Chun
出版源: 《Pharmacological Research》 ,2016 ,105 :146-151
摘要:Jumonji histone demethylases as emerging therapeutic targetsJumonji histone demethylasesEpigenetic regulatorCancerp53Abstract The methylation status of lysine residues in histones determines the transcription of surrounding genes by modulating the chromatin architecture. Jumonji domain-containing histone-lysine demethylases (Jmj-KDMs) remove the methyl moiety from lysine residues in ...
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目录:
  • Jumonji histone demethylases as emerging therapeutic targets
    • 1 Introduction
    • 2 Jumonji domain-containing histone-lysine demethylases
    • 3 Expression of Jmj-KDMs in human cancers
    • 4 Roles of the KDM7 subfamily in human diseases
    • 5 Roles of PHF2/KDM7C in human cancers
      • 5.1 Epigenetic regulations of p53-driven transcription
      • 5.2 PHF2 as an epigenetic activator of p53
      • 5.3 PHF2 as a prognostic cancer marker
    • 6 Concluding remarks
    • Acknowledgments
    • References

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