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标题:Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.
时间:2019-08-14 17:08:17
DOI:10.1007/s10549-015-3290-x
PMID:25667102
作者:Wang H;Shen W;Hu X;Zhang Y;Zhuo Y
出版源: 《Breast Cancer Research & Treatment》 ,2015 ,149 (3) :705-714
摘要:Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF-κB signaling pathways.QuetiapineBreast cancerBone metastasesOsteoclastBone resorptionBone loss is one of the major complications of advanced cancers such as breast cancer, prostate cancer, and lung cancer. Extensive research has revealed ...
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目录:
  • Quetiapine inhibits osteoclastogenesis and prevents human breast cancer-induced bone loss through suppression of the RANKL-mediated MAPK and NF- kappa B signaling pathways
    • Abstract
    • Introduction
    • Materials and methods
      • Cell culture
      • Cytotoxicity assay
      • TRAP staining of RAW 264.7 cells and BMMs
      • RNA isolation and RT-PCR analysis
      • Intramedullary injection of tumor cells
      • Assessment of osteolytic lesions in vivo
      • Immunofluorescent staining
      • Western blot
      • Statistical analysis
    • Results
      • QUE suppresses osteoclastogenesis of RAW 264.7 cells and BMMs induced by RANKL without cytotoxicity
      • QUE acts at the early step of RANKL-induced osteoclastogenesis
      • QUE inhibits the expression of osteoclastogenesis-related genes in RAW 264.7 cells and BMMs induced by RANKL
      • QUE inhibits osteoclastogenesis induced by tumor cells in vivo
      • QUE suppresses RANKL-induced activation of the MAPK and NF- kappa B pathways during osteoclast differentiation
    • Discussion
    • Conclusions
    • Acknowledgments
    • References

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