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标题:Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.
时间:2019-08-14 00:24:44
DOI:10.1083/jcb.201209135
PMID:23401004
作者:Jose A. Martina;Rosa Puertollano
出版源: 《Journal of Cell Biology》 ,2013 ,200 (6) :475-91
摘要:Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomesautophagylysosomesMITFRRAGMTORC1TFEBWhen the levels of intracellular amino acids are high, RRAG GTPases recruit MTORC1 to lysosomes and promote its activation. We found that RRAGs also recruit specific MTORC1 substrates to the lysosomal surface, thus facilitating MTORC1-mediated phosphorylation...
大小:5126 kb
页数:18 PAGES
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