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标题:Effects of vercirnon on the activity of CYP3A4, CYP2C19 and CYP2C8 enzymes and BCRP and OATP1B1 transporters using probe substrates.
时间:2019-08-13 23:31:03
DOI:10.1007/s00228-013-1592-7
PMID:24100471
作者:Lynda J. Haberer;Iain McSherry;Anna Cargill;Linda McCarthy
出版源: 《European Journal of Clinical Pharmacology》 ,2014 ,70 (1) :37-45
摘要:Effects of vercirnon on the activity of CYP3A4, CYP2C19 and CYP2C8 enzymes and BCRP and OATP1B1 transporters using probe substratesDrug interactionVercirnonCYP3A4CYP2C19CYP2C8BCRPOATP1B1Vercirnon is a CCR9 chemokine receptor antagonist being developed for the treatment of Crohn’s disease. As a variety of concomitant medications are often required for the ...
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目录:
  • Effects...
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Introduction
    • Methods
      • Subjects
      • Study design and treatments
      • Sample size considerations
      • Study population
      • Pharmacokinetic analysis
      • Statistical analysis
        • Probe assessment
        • Vercirnon steady-state analysis
      • Safety
      • Pharmacogenetic analyses
    • Results
      • Subjects
      • Pharmacokinetics
        • Probe and treatment comparisons
        • Vercirnon and metabolites—accumulation and steady-state assessment
      • Safety
      • Pharmacogenetics
    • Discussion
    • References

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