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标题:Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.
时间:2019-07-12 22:05:16
DOI:10.1016/j.bbrc.2013.09.028
PMID:24041688
作者:Xu, Jie;Zeng, Li-Fan;Shen, Weihua;Turchi, John J.;Zhang, Zhong-Yin
出版源: 《Biochemical & Biophysical Research Communicati... ,2013 ,439 (4) :586-590
摘要:Targeted therapy with inhibitors of epidermal growth factor receptor (EGFR) has produced a noticeable benefit to non-small cell lung cancer (NSCLC) patient...
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目录:
  • Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma
    • 1 Introduction
    • 2 Methods
      • 2.1 Cell culture and reagents
      • 2.2 RNA interference studies
      • 2.3 Cell proliferation assay
      • 2.4 Human NSCLC tumor xenograft experiments
      • 2.5 Statistical analysis
    • 3 Results
      • 3.1 Effect of SHP2 siRNA on H1975 cells proliferation and ERK1/2 activation
      • 3.2 SHP2 inhibitor II-B08 decreases H1975 cell proliferation and EGF-mediated ERK1/2 activation
      • 3.3 II-B08 blocks SHP2-dependent signaling
      • 3.4 SHP2 inhibitor II-B08 suppresses H1975 xenograft tumor growth
      • 3.5 SHP2 inhibitor II-B08 synergizes with PI3K inhibitor in suppressing H1975 cell growth
    • 4 Discussion
    • Acknowledgments
    • Appendix A Supplementary data
    • References

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