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标题:The design of covalent allosteric drugs.
时间:2019-07-12 21:23:26
DOI:10.1146/annurev-pharmtox-010814-124401
PMID:25149918
作者:Nussinov, Ruth;Tsai, Chung-Jung
出版源: 《Annual Review of Pharmacology & Toxicology》 ,2015 ,55 (55) :249
摘要:A key issue in drug discovery is how to reduce drug dosage and increase specificity while retaining or increasing efficacy, as high dosage is often linked ...
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页数:23 PAGES
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目录:
  • Annual Reviews Online
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  • All Articles in the Annual Review of Pharmacology and Toxicology, Vol. 55
    • A Conversation with Susan Band Horwitz
    • Introduction to the Theme “Precision Medicine and Predictionin Pharmacology”
    • Identifying Predictive Features in Drug Response Using MachineLearning: Opportunities and Challenges
    • Predicting Toxicities of Reactive Metabolite–Positive Drug Candidates
    • The Use of Biomarkers in Human Pharmacology (Phase I) Studies
    • Improving Postapproval Drug Safety Surveillance: Getting BetterInformation Sooner
    • Preemptive Clinical Pharmacogenetics Implementation: CurrentPrograms in Five US Medical Centers
    • A Personalized Medicine Approach for Asian Americans with theAldehyde Dehydrogenase 2*2 Variant
    • Pharmacogenomics in Asthma Therapy: Where Are We and Where Do We Go?
    • Drug Disposition in Obesity: Toward Evidence-Based Dosing
    • How Good Is “Evidence” from Clinical Studies of Drug Effects andWhy Might Such Evidence Fail in the Prediction of the Clinical Utility of Drugs?
    • The Ethics and Economics of Pharmaceutical Pricing
    • Brown, Beige, and White: The New Color Code of Fat and Its Pharmacological Implications
    • Candidate Drug Targets for Prevention or Modification of Epilepsy
    • The Design of Covalent Allosteric Drugs
    • Therapeutic Modulation of Urinary Bladder Function: MultipleTargets at Multiple Levels
    • Mineralocorticoids in the Heart and Vasculature: New Insights for Old Hormones
    • Unraveling the Physiological Complexities of Antibiotic Lethality
    • Intraclass Differences Among Antihypertensive Drugs
    • Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases
    • New Approaches to Inhibiting Platelets and Coagulation
    • DREADDs (Designer Receptors Exclusively Activated by DesignerDrugs): Chemogenetic Tools with Therapeutic Utility
    • Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer’s Disease and Beyond
    • Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions
    • Eph Receptors and Ephrins: Therapeutic Opportunities
    • Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy
    • Synthetic Lethal Vulnerabilities of Cancer
    • Calcitonin Gene-Related Peptide (CGRP): A New Target for Migraine
    • Activation and Regulation of Caspase-6 and Its Rolein Neurodegenerative Diseases
    • Constellation Pharmacology: A New Paradigm for Drug Discovery
    • DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics
    • Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier
    • Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

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