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标题:Mitochondrial biogenesis and the development of diabetic retinopathy.
时间:2019-07-12 18:48:30
DOI:10.1016/j.freeradbiomed.2011.08.017
PMID:21911054
作者:Santos JM;Tewari S;Goldberg AF;Kowluru RA
出版源: 《Free Radical Biology & Medicine》 ,2011 ,51 (10) :1849-1860
摘要:Mitochondrial biogenesis and the development of diabetic retinopathy.Diabetic retinopathyDNA damageMitochondriaSuperoxide dismutaseFree radicals► Retinal mitochondria biogenesis is impaired in diabetes. ► Transport of TFAM to the mitochondria is responsible for impaired biogenesis. ► Regulation of oxidative stress protects abnormalities in mitochondria biogenesis.doi:10.1016/j.free...
大小:1196 kb
页数:13 PAGES
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目录:
  • Mitochondrial biogenesis and the development of diabetic retinopathy
    • Methods
      • Mice
      • Retinal endothelial cells
      • Human retinas
      • Sample preparation
      • Gene expression
      • Mitochondrial DNA damage
      • Mitochondrial copy number and mass
      • Protein expression
      • Mitochondrial functional integrity
      • Interactions between TFAM and Hsp70
      • Statistical analysis
    • Results
      • Effects of diabetes on mitochondrial DNA damage and biogenesis in mouse retina
      • Effect of overexpression of MnSOD on mitochondria biogenesis
      • Mitochondrial biogenesis in retinal endothelial cells and regulation by MnSOD
      • Human retina
    • Discussion
    • Acknowledgments
    • References

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