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标题:A thermosensitive liposome prepared with a Cu²⁺ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy.
时间:2019-07-12 15:02:21
DOI:10.1016/j.jconrel.2012.03.023
PMID:22504351
作者:Tagami T;May JP;Ernsting MJ;Li SD
出版源: 《Journal of Controlled Release Official Journal... ,2012 ,161 (1) :142-149
摘要:Here we report the development of an enhanced thermosensitive formulation composed of DPPC and Brij78, loaded with doxorubicin (DOX) using a Cu 2+ gradient...
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目录:
  • A thermosensitive liposome prepared with a Cu2+ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy
    • 1. Introduction
    • 2. Materials and methods
      • 2.1. Materials
      • 2.2. Preparation of DOX-loaded liposomes
      • 2.3. Preparation of HaT-II formulation
      • 2.4. In vitro release of DOX from liposomes
      • 2.5. Animals and tumor cells
      • 2.6. PK study
      • 2.7. Biodistribution study
      • 2.8. Antitumor efficacy study
      • 2.9. Statistical analysis
    • 3. Results
      • 3.1. Drug release profiles and formulation characterization
      • 3.2. Blood PK
      • 3.3. Biodistribution study
      • 3.4. Antitumor efficacy study
      • 3.5. Toxicological analysis
    • 4. Discussion
    • Acknowledgements
    • Supplementary data
    • References

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