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标题:Effects of occlusal disharmony on the hippocampal dentate gyrus in aged senescence-accelerated mouse prone 8 (SAMP8).
时间:2019-07-12 14:57:26
DOI:10.1016/j.archoralbio.2016.01.015
PMID:26874024
作者:Mori D;Miyake H;Mizutani K;Shimpo K;Sonoda S
出版源: 《Archives of Oral Biology》 ,2016 ,65 (45) :95-101
摘要:Effects of occlusal disharmony on the hippocampal dentate gyrus in aged senescence-accelerated mouse prone 8 (SAMP8)MalocclusionHippocampusNeurogenesisApoptosisBDNFMalocclusion induced by raising the bite causes chronic stress. Chronic stress leads to increased plasma corticosterone levels and impaired hippocampal function due to impaired neurogenesis or increased apoptosis in the ...
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目录:
  • Effects of occlusal disharmony on the hippocampal dentate gyrus in aged senescence-accelerated mouse prone 8 (SAMP8)
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 Animals and experimental protocol
      • 2.2 Bite-raised condition (raised occlusal vertical dimension)
      • 2.3 5-Bromodeoxyuridine (BrdU) treatment
      • 2.4 BrdU immunohistochemistry
      • 2.5 Double immunohistochemistry
      • 2.6 Terminal deoxyribonucleotidyl transferase dUTP nick-end labeling (TUNEL) assay
      • 2.7 BDNF mRNA expression
      • 2.8 BNDF protein assay
      • 2.9 Data analysis
      • 2.10 Statistics
    • 3 Results
    • 4 Discussion
    • Conflict of interest
    • Funding
    • Acknowledgement
    • References

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