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标题:Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes.
时间:2019-07-12 13:58:17
DOI:10.1016/j.neuropharm.2018.01.001
PMID:29305122
作者:FJ Kong;JH Wu;SY Sun;LL Ma;JQ Zhou
出版源: 《Neuropharmacology》 ,2018 ,131 :316-325
摘要:Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes.Abstract Diabetic cognitive dysfunction has gained widespread attention for its deleterious impact on individuals with diabetes. However, few clinical interventions are available to prevent the ...
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目录:
  • Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of r ...
    • 1. Introduction
    • 2. Materials and methods
      • 2.1. Animals and study design
      • 2.2. Cell culture and treatments
      • 2.3. Behavioral studies
        • 2.3.1. Open-field test
        • 2.3.2. Morris Water Maze test
      • 2.4. Hematoxylin and eosin staining
      • 2.5. Nissl staining
      • 2.6. Double immunofluorescence labeling
      • 2.7. Transmission electron microscopy
      • 2.8. Western blotting analysis
      • 2.9. Real-time quantitative polymerase chain reaction
      • 2.10. Statistical analysis
    • 3. Results
      • 3.1. Effect of liraglutide on metabolic parameters in mice
      • 3.2. Liraglutide improves diabetes-induced learning and memory impairments in mice
      • 3.3. Liraglutide alleviates diabetes-induced hippocampal neuronal injuries and synaptic ultrastructure degradation in mice
      • 3.4. Liraglutide activates autophagy in mice
      • 3.5. The AMP-activated protein kinase/mammalian target of rapamycin pathway is involved in liraglutide-induced autophagy in hipp ...
    • 4. Discussion
    • Funding
    • Conflicts of interest
    • Acknowledgments
    • References

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