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标题:Mechanisms and Biological Consequences of Peroxynitrite-Dependent Protein Oxidation and Nitration
时间:2019-07-12 00:16:25
DOI:10.1016/B978-0-12-373866-0.00003-4
作者:Madia Trujillo;Beatriz Alvarez;José M. Souza;Natalia Romero;Laura Castro
摘要:This chapter presents the mechanisms of reaction between peroxynitrite and amino acid residues as well as prosthetic groups in proteins. It analyzes the selected examples of such protein modifications and their biological consequences. P...
大小:694 kb
页数:43 PAGES
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目录:
  • Mechanisms and Biological Consequences of Peroxynitrite-Dependent Protein Oxidation and Nitration
    • Summary
    • Overview of peroxynitrite biochemistry
    • Peroxynitrite-mediated amino acid and protein modifications
      • Cysteine oxidation
        • Human serum albumin
        • Peroxiredoxins
      • Selenocysteine oxidation
        • Glutathione peroxidase I
      • Methionine oxidation
        • Alpha 1-antitrypsin
      • Tryptophan oxidation
        • Human CuZnSOD
      • Reactions with metal-containing protein cofactors
        • Oxyhemoglobin
        • Aconitases
      • Peroxynitrite reactions with coenzymes
      • Tyrosine nitration and other oxidative modifications
        • Mechanisms of tyrosine reaction with peroxynitrite
        • Tyrosine nitration by •NO and O2•– fluxes
        • Effects of protein tyrosine nitration
        • Metal-catalyzed tyrosine nitration: the example of MnSOD
        • Uncatalyzed tyrosine nitration: the example of cytochrome c3 
      • Other protein modifications: carbonyl formation and protein fragmentation
      • Intramolecular electron transfer: when final amino acidic modification differs from initial site of reaction
      • Multiple amino acidic modifications
    • Biological consequences of peroxynitrite-mediated protein oxidation and nitration
      • Loss vs gain of function
      • Tyrosine oxidation and nitration involved in protein aggregation
      • Protein degradation
      • Peroxynitrite as a signaling mediator
      • Protein 3-nitrotyrosine as an antigen
    • Conclusions
    • Acknowledgments
    • References

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