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标题:RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
时间:2019-06-12 18:55:31
作者:Xiang Y;Laurent B;Hsu CH;Nachtergaele S;Lu Z
出版源: 《Nature》 ,2017 ,552 (7685) :573-576
摘要:Abstract Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment. A sys...
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目录:
  • RNA m6A methylation regulates the ultraviolet-induced DNA damage response
    • Authors
    • Abstract
    • References
    • Acknowledgements
    • Author Contributions
    • Figure 1 Modification at m6A on RNA accumulates at sites of DNA damage after UV exposure.
    • Figure 2 METTL3/14 and FTO oppositely regulate m6A RNA at DNA damage sites.
    • Figure 3 METTL3 is important for UV-induced DNA damage repair and cell survival.
    • Figure 4 Pol κ localization to damage sites is METTL3-dependent.
    • Extended Data Figure 1 The m6A-modified RNA accumulates at damage sites in response to UV irradiation.
    • Extended Data Figure 2 METTL3/14, but not WTAP, regulate m6A RNA at damage sites.
    • Extended Data Figure 3 FTO, but not ALKBH5, modulates m6A RNA levels and duration at damage sites.
    • Extended Data Figure 4 METTL3, FTO, and PARP1 regulate m6A RNA at damage sites.
    • Extended Data Figure 5 Sequencing analysis of m6A-methylated RNAs responding to UV.
    • Extended Data Figure 6 RNA with m6A modification is required for efficient DNA repair and cell survival after UV exposure.
    • Extended Data Figure 7 RNA with m6A modification does not interact with canonical NER or DSB repair pathways.
    • Extended Data Figure 8 RNA with m6A modification recruits Pol κ to damage sites.
    • Extended Data Figure 9 The m6A readers and known Pol κ interactors are not responsible for early Pol κ recruitment to UV damage sites.
    • Extended Data Figure 10 Knockdown efficiencies of candidates tested for their effects on Pol κ recruitment.

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